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HPAPI Capsule Inspection System


HPAPI Capsule Inspection System is designed to provide personnel protection during the inspection of filled capsules containing Highly Potent Active Pharmaceutical Ingredient (HPAPI) powder. Accommodates space for an analytical weighing balance and capsule inspection bats (paddles). Acrylic viewing panels above enclosure face provide continuous, uninterrupted line of sight during inspection processes. Inspected product may be safely removed from the enclosure by inserting material through a continuous liner cut-out located in the center of the enclosure base. Waste is removed from the right-side continuous liner.

Features include removable draftshield with 8” oval glove ports, dished phenolic base, two 24” (W) x 14” (D) dual-speed fans with Bag-in/Bag-out Dual HEPA filtration, 8” continuous liners on the left and right sides of the enclosure, magnifying glass mounting plate, polypropylene accessory plate, (2x) 220V dual outlets, E-Stop button with reset and on/off indication functionalities, four RJ45 Ethernet connections, FS1650 alarm, control box with fan/light switch and isolation switch. LED lighting and acrylic viewing panels provide optimal lighting across the working surface. Includes a stainless steel table with height-adjustment functionality, leveling pads, lockable casters, and a 19” (H) CPU shelf.


91” Exterior Width

30” Exterior Depth

27” Interior Height

FSI Category: 10+


SAFETY.  The Hybrid Isolator series provides containment for highly toxic applications using APIs that need more safety than an opened face enclosure. FSI engineering controls are built in to prevent loss of containment. Third Party testing has proven containment on these units to below 50 ng/m3 based on process and quantity.

DESIGN.  Designed as the next step in containment above the Top Mounted CVE, this unit is able to effectively contain using airfoils and plenums to create laminar airflow across the work surface and reduce eddies and turbulence. The Hybrid Isolator system is equipped with dual 4” HEPA filters that can be recirculated into the lab or sent directly to house exhaust.

PHENOLIC BASE. The chemically resistant phenolic base is dished to maintain spills and protects the work surface from harmful chemicals.

DUAL SPEED FAN.  This enclosure includes a 2 speed adjustable fan that automatically switches between high and low speed depending on the draft shield being attached or unattached.

ACRYLIC WALLS.  The clear acrylic walls are used for increased ambient light transmission.

INTERNAL LED LIGHT.  This enclosure features an internal LED light for improved visibility inside of the enclosure and can be adjusted directly onto the application. This light comes standard with every Hybrid Isolator Enclosure.

STANDARD SIZES.  The Hybrid Isolator series is available in 3, 4, 5, 6, and 8 foot standard width options. Customs are available.

With the explosion in usage of High Potency Active Pharmaceutical Ingredients (HPAPI’s), containment of these compounds and personnel protection have become of major concern to scientists. There is often a high expense associated with new equipment designed to handle the task. In order to combat these potentially high capital outlays, many companies are looking at alternative methods of containment, including modification of existing equipment. The Hybrid Isolator, offered by Flow Sciences, Inc., is one such method of reducing the cost of containment.

The Hybrid Isolator is designed to protect workers from exposure to chemicals by fully encompassing equipment used by scientists during research and development, and manufacturing processes. The Isolator has been developed using Flow Sciences’ expertise in Computational Fluid Dynamics (CFD) and can be designed and manufactured to fit the customer’s needs.

Air distributes evenly, without roll, across the HEPA filters and leaves through an adjustable speed fan with integrated alarm.

Blue indicates gentle, low velocity ambient room air entering
over the air foils and being pulled across the work surface
through the rear plenums.

A Velocity Profile demonstrates the gentle airflow across the work surface shown in blue.

A Particle Trace shows the distribution of particulates as they travel to the back plenums of the enclosure, through the HEPA filters and out of the exhaust port.

Exhaust Options

Exhaust Option B


Exhaust Option G




Get a Quote / Info

  • What is being done inside of the enclosure? What type of material (powder, liquid, gas, nuisance odor) is being worked with? How does the material enter and exit the enclosure system? etc...
  • What type of filtration is required? Single HEPA, Dual HEPA, Carbon, House Exhaust, etc... What is the required OEL (Occupational Exposure Limit) for the process, or any other details about containment goals? What is the quantity of powder or liquid, task duration, composition of powder, etc...?
  • What equipment is being worked with? What is the equipment model, size, scope, function, and any other information that will affect the design of the enclosure, including movement, heat output, etc...? *State the specific equipment make and model if available*
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  • Are there any additional notes or information that should be considered? Are there any special design requirements?

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 2025 Mercantile Dr., Leland, NC 28451
 Phone: 1-800-849-3429
 Fax: (910) 763-1220

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