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Hybrid Isolator with Getinge La Calhene RTP Port designed to provide personnel protection down to a respiratory concentration of 5 nanograms per cubic meter air (5 ng/m3). Enclosure features a polypropylene superstructure, removable draftshield with (4x) 8” diameter oval glove ports, (2x) top mount fan / filter housings with Dual-HEPA filtration (aka. redundant HEPA filtration), and stainless steel electrical control box with fan and light switches. Includes a 10’ (3.048m) unit power cord for the stainless steel electrical control box.

Accommodates space for (2x) Mettler Toledo analytical balances. Base (aka. workspace) coated in black phenolic resin for error attenuation for mass measurement data; base is dished to control spills.

An Alpha- 270mm (10.63”) diameter Getinge La Calhene Rapid Transfer Port (RTP) System on right side of enclosure facilitates connection to the conjugate Beta- port for safe transport of material into and out of the enclosure.

Additional features include:

  • Automatic toggling between two fan rotational speeds upon removal / replacement of draftshield
  • Bag-In-Bag-Out (BIBO) functionality for safe replacement of primary HEPA filter
  • Stainless steel electrical control box features switch for LED Lighting for optimal viewing across the workspace
  • Integrated airflow velocity alarm, which alerts the user when face velocity measurement is lower than the setpoint calibrated by the certifier
  • 3” diameter rubber membrane iris port on left side facilitates entry / egress of equipment cables and cords
  • Minihelic gauge for real-time display of differential pressure measurement between primary and secondary HEPA filters
  • 10” [3048mm] diameter hole on left side to facilitate connection to another FSI enclosure or another compatible non-Flow Sciences enclosure; includes cover to retain containment when not in use


External Width: 57.75” (workspace); 85.19” (overall)
External Depth: 30.25”
Internal Height: 26.51”

FSI Category 9-10


SAFETY.  The Hybrid Isolator series provides containment for highly toxic applications using APIs that need more safety than an opened face enclosure. FSI engineering controls are built in to prevent loss of containment. Third Party testing has proven containment on these units to below 50 ng/m3 based on process and quantity.

DESIGN.  Designed as the next step in containment above the Top Mounted CVE, this unit is able to effectively contain using airfoils and plenums to create laminar airflow across the work surface and reduce eddies and turbulence. The Hybrid Isolator system is equipped with dual 4” HEPA filters that can be recirculated into the lab or sent directly to house exhaust.

PHENOLIC BASE. The chemically resistant phenolic base is dished to maintain spills and protects the work surface from harmful chemicals.

DUAL SPEED FAN.  This enclosure includes a 2 speed adjustable fan that automatically switches between high and low speed depending on the draft shield being attached or unattached.

ACRYLIC WALLS.  The clear acrylic walls are used for increased ambient light transmission.

INTERNAL LED LIGHT.  This enclosure features an internal LED light for improved visibility inside of the enclosure and can be adjusted directly onto the application. This light comes standard with every Hybrid Isolator Enclosure.

STANDARD SIZES.  The Hybrid Isolator series is available in 3, 4, 5, 6, and 8 foot standard width options. Customs are available.

With the explosion in usage of High Potency Active Pharmaceutical Ingredients (HPAPI’s), containment of these compounds and personnel protection have become of major concern to scientists. There is often a high expense associated with new equipment designed to handle the task. In order to combat these potentially high capital outlays, many companies are looking at alternative methods of containment, including modification of existing equipment. The Hybrid Isolator, offered by Flow Sciences, Inc., is one such method of reducing the cost of containment.

The Hybrid Isolator is designed to protect workers from exposure to chemicals by fully encompassing equipment used by scientists during research and development, and manufacturing processes. The Isolator has been developed using Flow Sciences’ expertise in Computational Fluid Dynamics (CFD) and can be designed and manufactured to fit the customer’s needs.

Air distributes evenly, without roll, across the HEPA filters and leaves through an adjustable speed fan with integrated alarm.

Blue indicates gentle, low velocity ambient room air entering
over the air foils and being pulled across the work surface
through the rear plenums.

A Velocity Profile demonstrates the gentle airflow across the work surface shown in blue.

A Particle Trace shows the distribution of particulates as they travel to the back plenums of the enclosure, through the HEPA filters and out of the exhaust port.

Exhaust Options

Exhaust Option B


Exhaust Option G



Get a Quote / Info

  • What is being done inside of the enclosure? What type of material (powder, liquid, gas, nuisance odor) is being worked with? How does the material enter and exit the enclosure system? etc...
  • What type of filtration is required? Single HEPA, Dual HEPA, Carbon, House Exhaust, etc... What is the required OEL (Occupational Exposure Limit) for the process, or any other details about containment goals? What is the quantity of powder or liquid, task duration, composition of powder, etc...?
  • What equipment is being worked with? What is the equipment model, size, scope, function, and any other information that will affect the design of the enclosure, including movement, heat output, etc...? *State the specific equipment make and model if available*
  • Drop files here or
  • Are there any additional notes or information that should be considered? Are there any special design requirements?

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 Phone: 1-800-849-3429
 Fax: (910) 763-1220

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